E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.

Analysis of gross liver weights and number of macroscopically visible tumors suggested that E2F7 overexpression reduced DEN‐induced tumor burden, although differences did not reach statistical significance due to the large variation among animals (Fig. 4B ; Supporting Fig.

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This analysis revealed a highly significant decrease in the numbers of histologically detectable tumors in E2f7 and E2f8 Tg livers, as well as a reduction in the ratio between tumor and normal liver tissue (Fig. 4C,D ; Supporting Fig.

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