Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function.

NT β13 – β14/4Ala , NT Δβ20 – β 21 and NT Δβ31 – β 32, the latter serving as negative control, produced oligomers to the same extent as NT WT , whereas deletion of the β23–β24 sequence resulted in reduced tetramer formation (by 39% at 60 min) that did not reach statistical significance compared to WT.

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