9 , 44 Similarly, the unbound DOX plasma concentrations released from the L_DOX showed a trend and magnitude comparable to DOX with a decline to values below the minimum bound of the in vitro range of concentrations cytotoxicity range ( Figure 2 ).
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In vitro to Clinical Translation of Combinatorial Effects of Doxorubicin and Abemaciclib in Rb-Positive Triple Negative Breast Cancer: A Systems-Based Pharmacokinetic/Pharmacodynamic Modeling Approach.
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