Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis.

Finally, although alterations of the 5HT system have been associated to fatigue ( Dobryakova et al., 2015 , Hesse et al., 2014 ), we did not report significant correlation (except for a trend toward significance in the tract connecting MR to cerebellar-lobule VII), possibly due to the fact that we only investigated those bundles originating from raphe nuclei and projecting to the cerebellar cortex.

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The mesocortical tract displayed reduction in WM in MS patients in comparison of HC, although the difference did not reach statistical significance.

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