For the Mir183/96 dko homozygotes, we obtained eight networks for which their upstream regulators were given a significant or nearly significant z -score; Bdnf, Gh, H2afx (also known as H2ax), Kcna3, Kit, Myocd, Prkaca and Pth, which explain between them the misregulation of 14 genes ( Fig.
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Hearing impairment due to <i>Mir183/96/182</i> mutations suggests both loss and gain of function effects.
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