Early Intervention With Vedolizumab on Longer Term Surgery Rates in Crohn's Disease: Post Hoc Analysis of the GEMINI Phase 3 and Long-term Safety Programs.

Point estimates were similar when using more stringent definitions, which included a 2-year cut-off, or a 5-year cut-off with no previous bowel surgery or fistulising disease, thereby demonstrating a consistent signal of benefit for early disease intervention in this subgroup; however, these secondary definitions did not reach statistical significance due to sample sizes.

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