Interaction between cognitive reserve and age moderates effect of lesion load on stroke outcome.

Whereas none of the two-way interactions approached significance (all p > 0.463), the significant three-way interaction (p = 0.049) indicated that effects of lesion size on post-stroke cognitive outcome were moderated by both age and years of education (Fig. 3 B): In middle-aged stroke patients at ages around 66 years (Fig. 3 B, middle panel), the well-established negative association between cognitive outcome and lesion size was found independent of educational attainment, which itself was positively associated with cognitive outcome.

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