GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease.

Moreover, the ddPCR and western blot results showed that the expression of GRP4 was significantly lower in CAD individuals than in non-CAD individuals in an acidic environment, while the difference between groups did not reach statistical significance regardless of pH (Fig. 3 d, e).

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