Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?

When looking at one of the first papers of the Thayumanavan group in this field, 52 a clear trend could be observed from dye release experiments—a zero-generation (G0) dendron bearing a single hydrophilic chain and a single enzymatically cleavable aliphatic ester dissembled much faster than higher molecular weight dendrons (first- to third-generation dendrons), which showed significantly slower dye release and disassembly rates as the generation of the dendrons increased ( Figure 2 ).

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