Early localized alterations of the retinal inner plexiform layer in association with visual field worsening in glaucoma patients.

These associations detected between the decreasing IPL thickness (or IPL density) and the worsening of local visual field sensitivity scores were highly significant (P<0.001 for both IPL thickness and density).

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We recognize that although we found a significant positive correlation between the IPL thickness and IPL density (thereby providing an internal control) and also detected a significant trend of correlation between the local alterations of IPL density and corresponding visual field scores, additional studies with methodological improvements are warranted to further verify and expand presented observations of the IPL reflectance.

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