Serotonergic Innervations of the Orbitofrontal and Medial-prefrontal Cortices are Differentially Involved in Visual Discrimination and Reversal Learning in Rats.

This interaction was driven by different effects within the mPFC and OFC across the different stages: the lesion effect was significant during acquisition (one-way ANOVA: F 2,17 = 3.68; P = 0.047) and failed to reach significance during reversal 1 ( F 2,17 = 2.90; P = 0.083) and reversal 2 ( F 2,17 = 2.72; P = 0.094).

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Whereas the pairwise comparisons between the lesion groups failed to reach statistical significance, this interaction appeared to be driven by a decreased number of correction errors during the first reversal in the 5,7-DHT group and elevated numbers during the other two stages ( Fig. 4 e ).

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