In agreement with an increase in respiration, overall glycolytic activity as measured by ECAR shows a decreasing trend in HEK293A FMO-OE cells ( Figures 5A,B ).
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Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism.
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The cadmium LD 50 of FMO1, 2, 3, and 5 OE cells is increased compared to the control cells but did not reach statistical significance, while FMO4-OE is significant ( Figure 1G ).