Defective autophagy in Sf1 neurons perturbs the metabolic response to fasting and causes mitochondrial dysfunction.

Fasting-induced autophagy was not restricted to the VMH; the density of LC3-GFP puncta was also significantly higher in the ARH of fasted mice than in fed mice and elevated in the PVH as well, although it did not reach statistical significance ( Figure S1A–B ).

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