Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.

Transl Psychiatry · 2021 · PMC7910483 · PMID 33637690

Europe PMC DOI

hedged sentences

0.0035

closest p · 0.1× alpha

0.0900

boldest claim

The sentences

nominally significantp = 3.54E−03actually significant

The HRs were nominally significant in LOADFS ( p = 3.54E−03) and CHS ( p = 2.19E−02).

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a decreasing trendp = 0.09so close (0.05 < p ≤ 0.1)

The protective allele rs12373123-C was associated with elevated MAPT expression in astrocytes ( p = 0.01) while a decreasing trend in OPCs ( p = 0.09) (Fig. 4B and Table S5 ).

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