A randomized phase 1 single-dose polysomnography study of ASP8062, a GABA<sub>B</sub> receptor positive allosteric modulator.

Psychopharmacology (Berl) · 2021 · PMC7914186 · PMID 33433644

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an increasing trendno p-value reported

Results from the current PSG study suggest that ASP8062 has pharmacodynamic effects in the brain as demonstrated by a significant and likely dose-related increase in SWS over the entire night, in conjunction with an increasing trend in GH.

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did not reach statistical significanceno p-value reported

Thirty-five milligrams ASP8062 showed a similar trend with respect to stage N1 sleep time, but the changes did not reach statistical significance.

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