The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment.

33 Another IL-12 expressing oHSV, M002, showed a trend of improved median survival in three patient-derived pediatric or adult xenograft GBM models compared to unarmed G207. 58 Like 005 model, M002 was extremely efficient in an intracranial syngeneic 4C8 murine glioma model, since M002 treatment resulted in 80% long-term survivors. 59 Like IL-12, other cytokines such as FMS-like tyrosine kinase 3 ligand (Flt3L) or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were inserted into the backbone of G47∆ and generated G47∆-Flt3-L 60 and oHSV-TRAIL viruses, 61 respectively.

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