CRISPR Deletion of a SVA Retrotransposon Demonstrates Function as a <i>cis</i>-Regulatory Element at the <i>TRPV1/TRPV3</i> Intergenic Region.

Int J Mol Sci · 2021 · PMC7917899 · PMID 33671852

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a clear trendno p-value reported

The effect of these modifications is unclear; nevertheless, whilst not statistically significant, a clear trend emerged in heterozygous ΔSVA clones showing deregulation in both TRPV1 and TRPV3 expression when compared to unedited cells and the ratio of TRPV1:TRPV3 was disrupted in heterozygous ΔSVA clones, consistent with homozygous ΔSVA clones. 3.5.

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