Low Expression of IL-15 and NKT in Tumor Microenvironment Predicts Poor Outcome of MYCN-Non-Amplified Neuroblastoma.

To validate these findings, we evaluated the expression levels of Vα24 and IL-15 in our 53 NBL clinical samples and found that they were both higher in the MYCN-non-amplified group, although the differences did not reach statistical significance due to small sample size ( p = 0.15 and 0.19, respectively) ( Supplementary Figure S2 ). 3.2.

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Low IL-15 expression was associated with poorer EFS with borderline significance but was not significantly associated with OS ( p = 0.05 and 0.41, respectively) compared to high IL-15 expression ( Figure 5 B,E).

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