showed a trendp = 0,11
Finally, a recent phase II multicentre double-blind placebo-controlled trial of abatacept in early dcSSc showed a trend for a significant lower decline of FVC% predicted (mean difference 2.79, 95% CI −0,69–6,27, p = 0,11 favouring Abatacept), although the change in skin fibrosis as a primary endpoint was, again, not met [ 57 ].