Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial.

All implants showed bleeding on probing at some site at baseline (a peri-implantitis diagnostic criterion); the greatest reduction in bleeding was observed in the test group at 45 and 90 days, and the difference with control group 2 was borderline significant at 90 days.

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Radiological MBL measurements remained stable at 45 and 90 days in the test group, but increased in the control groups, although the differences did not reach statistical significance.

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