Furthermore, the multiplex group showed a trend toward greater reductions in default mode network (DMN) connectivity in the precuneus and anterior cingulate cortex (ACC) than the simplex group, suggesting that dysfunction in these regions is related to genetic risk for schizophrenia 27 .
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Reduced cortical gyrification in the posteromedial cortex in unaffected relatives of schizophrenia patients with high genetic loading.
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