29 In the 6 RCTs included, almost all showed a trend towards lower mortality in patients receiving combination therapy; however, only the RCT by Abdelsalam et al. found a significant difference in mortality. 54 The largest RCT by Paul et al. showed significant results in case of infections with K. pneumoniae , though not adequately powered for it. 42
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Polymyxin Monotherapy vs. Combination Therapy for the Treatment of Multidrug-resistant Infections: A Systematic Review and Meta-analysis.
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