Human Epidermal Growth Factor Receptor-3 Expression Is Regulated at Transcriptional Level in Breast Cancer Settings by Junctional Adhesion Molecule-A via a Pathway Involving Beta-Catenin and FOXA1.

Cancers (Basel) · 2021 · PMC7922773 · PMID 33669586

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Our preliminary data showed a trend towards increased YAP/TAZ protein expression in JAM-A overexpressing breast cancer cells ( Figure S18 ); potentially suggesting a mechanism to account for increased β-catenin expression and transcriptional activity in the JAM-overexpressing tumorigenic cellular model.

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