Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics.

This second proposed mechanism is strongly supported by our finding of a highly significant negative correlation between the ratio of AT activity/AT antigen level and thrombin half-life.

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While there was a tendency to longer plasma half-lives of human thrombin with lower AT levels, the correlations of plasma half-life with thrombin-based AT level, FXa-based AT level, and AT antigen level did not reach statistical significance.

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