A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.

Elife · 2021 · PMC7924951 · PMID 33587034

Europe PMC DOI

hedged sentences

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

showed a trendp-value=0.13not close (p > 0.1)

The Six2DE showed a trend of greater accessibility in low CHIR versus high CHIR condition (peak ID 10164, adjusted p-value=0.13).

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highly significantno p-value reported

Comparing NPC gene expression profiles in low CHIR versus no CHIR conditions revealed highly significant GO enrichment in cell cycle-related terms ( Figure 1—figure supplement 1E ), consistent with pro-proliferation roles of β-catenin in self-renewing NPCs.

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