Thalamic morphology predicts the onset of freezing of gait in Parkinson's disease.

NPJ Parkinsons Dis · 2021 · PMC7925565 · PMID 33654103

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hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

a trend towards significanceP = 0.052so close (0.05 < p ≤ 0.1)

Global volume differences at study entry and over two years At study entry ( N = 57), differences in global volumes with a trend towards significance were found in the brainstem ( P = 0.052).

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approaching significanceno p-value reported

Longitudinaly ( N = 43), permutation testing revealed that converters and non-converters showed significantly different local shape alterations over two years in the brainstem ( P FWE max = 0.045), and clusters approaching significance in the left thalamus ( P FWE max = 0.06) and left amygdala ( P FWE max = 0.083).

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