High Concentrations of Etanercept Reduce Human Islet Function and Integrity.

7 , 8 This adjunctive therapy has resulted in a highly significant improvement of all functional parameters of transplanted islets. 3 , 9 Since its introduction for islet transplantation almost 15 years ago, 10 the protocol for peri-transplant administration (50 mg intravenously 1 hour pre-transplant, followed by 25 mg subcutaneously on days 3, 7 and 10 post-trans

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Although a slight reduction of the BAX-over-BCL-2 mRNA ratio could be detected, the decrease of pro-apoptotic BAX did not reach statistical significance.

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