showed a trendp = 0.0586
The cumulative temperature increase, i.e., the actually recorded temperature over a 9-day period with normal circadian temperature pattern subtracted was significantly higher in the combined-route group than in the aerosol–BAL group ( p = 0.0085), while the difference with the aerosol group did not reach the threshold for significance but only showed a trend ( p = 0.0586).