Barely Significant
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Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case-control study.

J Transl Med · 2021 · PMC7927388 · PMID 33653375

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a significant trendno p-value reported
In addition, serum DD levels of pregnant women showed a gradually increasing trend with the progression of HDP, suggesting that DD seems to be the most promising of those markers, with a significant trend related to severity of the disease.

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