Immunoprecipitation of the nBCR and tBCR with PCNSL lysates was limited due to tissue scarcity with low protein content; nevertheless, there was a tendency towards increased numbers of proteins recognized by tBCR compared to nBCR, which, however, did not reach statistical significance ( Online Supplementary Figure S5 ).
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The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.
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