Adjuvant therapy in non-ulcerated melanomas with macro-metastases was associated with the smallest RFS benefit and did not reach statistical significance (HR 0.73; 95%CI= 0.50–1.05) ( eFigure 4, supplement ).
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Adjuvant Therapy of High-Risk (Stages IIC-IV) Malignant Melanoma in the Post Interferon-Alpha Era: A Systematic Review and Meta-Analysis.
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