No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis.

Front Genet · 2021 · PMC7931909 · PMID 33679875

Europe PMC DOI

hedged sentences

0.0411

closest p · 0.8× alpha

0.0411

boldest claim

The sentences

nominally significantP = 4.11 × 10 –2actually significant

Results IVW showed a nominally significant effect of HRI on CV events (odds ratio [OR] = 1.0012, P = 4.11 × 10 –2 ) and on CAD and AF.

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highly significantno p-value reported

Conclusion Our findings suggest no strong evidence of an association between HRI and HRR and any outcome and confirm prior work reporting a highly significant effect of resting HR on AF.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.