Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19.

Levels of mitochondrial cytochrome c oxidase III (MT-COX3), another MT-DNA–encoded gene ( Supplemental Figure 1B ; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.143299DS1 ), revealed an increased trend in subjects who died [5.63 (5.00–6.46), n = 25] relative to those who survived [5.32 (4.90–5.83), n = 72] but did not reach statistical significance ( P = 0.1).

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