Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders.

At early postnatal period, VPA rats showed significantly lower body weight at PND14 and scored lower than controls in the swimming test at PND12; both parameters did not reach statistical significance at PND7 and 8, respectively, indicating that growth and maturation deficits in the VPA group became evident later than PND7 (Fig. 2 a).

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