Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy.

As expected, Tert expression was significantly increased in cultured neurons as well as due to activator treatment in line D mice with the exception that TA-65 in males did not reach statistical significance which could be due to a low mouse number in this group (n = 3).

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For females, the stride length of both feet (left and right) as well their variations were highly significant for both telomerase activators ( Fig. 3 B, C, E andF).

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