The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

J Biol Chem · 2020 · PMC7939464 · PMID 33093176

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did not reach statistical significanceno p-value reported

Of note, we previously observed insignificant shortening of APD in 3-week-old rabbit cardiomyocytes overexpressing LITAF in agreement with computer modeling results (data not shown), whereas morpholino-mediated down-regulation of LITAF in zebrafish embryos resulted in prolongation of APD that did not reach statistical significance ( 27 ).

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