Association between sex hormones regulation-related SNP rs12233719 and lung cancer risk among never-smoking Chinese women.

Our finding suggests that the SNP rs12233179 in sex hormones regulation may be significant in Chinese female NSCLC, and provides new insight into the possible role of ovarian sex steroid hormones in lung cancer. 6 ETHICS APPROVAL AND CONSENT TO PARTICIPATE This study was approved by the Medical Ethics Committees of Human Studies at China Medical University, and written information consent was signed by each participant.

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Under the dominant model, compared to individuals with the wild G/G genotype, the adjusted OR of those with the T allele was 1.58 (95% CI: 1.15–2.16) in Chinese Shenyang training set, and was 1.49 (95% CI: 1.02–2.18) in Chinese Tianjin validation set, both accompanied with a significant trend relationship consistently.

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