The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey.

Beginning on Study Day 92 through the end of the dosing phase, dP/dtmin values were lower in the dark cycle by 881–1,125 mmHg/s (−35 to −43%) in doxorubicin-treated animals compared with controls, with statistical significance noted at most time points; a similar pattern and magnitude was evident in the light cycle but did not reach statistical significance ( Figure 4 , Table 4 ).

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