Pre-existing Immunity to Japanese Encephalitis Virus Alters CD4 T Cell Responses to Zika Virus Inactivated Vaccine.

Comparisons between groups and time-points did not reach statistical significance as determined by Kruskal-Wallis followed by Dunn's multiple comparison test.

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There was no significant difference in ZIKV microneutralization titers between the vaccine groups at either week 30 (peak time-point) or week 52 (last time-point) ( Figure 6A ), but we observed a decreasing trend in these titers in both pre-vaccinated groups compared to flavivirus-naïve group at week 52.

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