Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent.

Interestingly, the proton signal from the t- Bu group showed a clear trend of upfield shift with the increase of concentration (Fig. 4b , Supplementary Fig. 45 ), based on which the dimeric association constant of HUM1 in CDCl 3 was determined to be around 5.5 M −1 (Supplementary Fig. 46 ).

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