Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.

J Biol Chem · 2021 · PMC7948410 · PMID 33172889

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highly significantno p-value reported

In addition, the ratio of mF-BRI2 to immature F-BRI2 precursor proteins was lower in Itm2b F-B and Itm2b F-D as compared with Itm2b F-WT transfected cells: this difference was highly significant for Itm2b F-D samples ( Fig. 3 , A – B ).

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did not reach statistical significanceno p-value reported

In this set of studies, facilitation at 50 ms ISI was increased in Itm2b KO/KO : however, this increase did not reach statistical significance ( Fig. 1 I ).

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