CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice.

In the BMM cultures supplemented with M-CSF, we observed significantly higher levels of Ccr2 , Ccl2 , and Ccr5 mRNAs in Ccr3 −/− than in Ccr3 +/+ cells, and this difference was apparent up to 48 h ( Ccr2 and Ccl2 ) and 72 h ( Ccr5 ) after seeding ( Fig. 3 , A – C ).

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