Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes.

Aging (Albany NY) · 2021 · PMC7950289 · PMID 33601339

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a weak trendno p-value reported

Since downregulation of DNA repair genes has previously been observed in senescence [ 20 ], we were surprised to find only a weak trend toward downregulation of these genes in our dataset.

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a strong trendno p-value reported

The mRNA for 24 of these IRDS genes was differentially expressed in NOKs with senescence, with a strong trend of upregulation ( Figure 5I ).

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