Similarly, at 2 h, transcription of the pro-inflammatory cytokine interleukin 1 beta (IL1-β), showed a trend towards an increase in the RN2N IgG2a treated cells compared to those treated with tau alone or in the presence of RN2N IgG1, and this effect was also absent at 8 h (Fig. 2 c).
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Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice.
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