MK2-Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload.

Two weeks after TAC, echocardiographic imaging revealed LV mass increased by 47% (sham: 103±3 mg, n=17; TAC: 151±8 mg, n=16; P <0.0001) in MK2 +/+ mice, which was attenuated to an increase of 9% in MK2‐deficient mice that did not reach statistical significance (sham: 112±6 mg, n=14; TAC: 128±7 mg, n=15; P >0.05).

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