Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats.

The GHS-R1A antagonist (1 and 3 mg/kg JMV2959) that was administered together with THC during conditioning dose-dependently reduced the development of (biased) CPP; but only the higher dose induced a highly significant effect ( p < 0.001).

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In addition, values within the ghrelin group were rather spread (110–642% of the baseline mean) similarly to the saline group (77–565% of the baseline mean); thus, the comparison between the saline and ghrelin groups did not reach statistical significance in the relapse-test session.

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