Barely Significant
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A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population.

J Clin Lab Anal · 2021 · PMC7957978 · PMID 33382484

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a clear trendno p-value reported
In addition, when CBS hypomethylation and DHFR hypomethylation were combined as biomarkers, there was a clear trend toward an increasing risk of stroke with increasing number of elevated biomarkers from 0 to 2.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.