Interestingly, an earlier study that performed RNA-seq within isolated platelets has observed decreased expression of PF4 and PPBP with age ( n = 154 [ 25 ]), while studies in whole blood show upregulation with age (current study: both genes significant; in the previous study [ 3 ]: PF4 not tested, PPBP nominally significant).
← all excerpts
Correction for both common and rare cell types in blood is important to identify genes that correlate with age.
1
—
—