Treatment Strategy in Human Ocular Toxoplasmosis: Why Antibiotics Have Failed.

Although the opinion about the need to treat varies greatly among uveitis experts, there seems to exist a generally accepted first choice treatment in the aforementioned surveys: the combination of pyrimethamine and sulfadiazine (PY/SA) with or without systemic corticosteroids seems to represent today’s gold standard for treating systemic as well as OT, whereas there exists a clear trend away from this side-effect-affected combination therapy to the fixed combination therapy with trimethoprim 160 mg and sulfamethoxazole 800 mg (TMP/SMZ) [ 34 ], which demonstrates a similar clinical effect as PY/SA, but has—in the absence of a sulfonamide allergy—an excellent safety profile [ 63 ].

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