Gene engineered mesenchymal stem cells: greater transgene expression and efficacy with minicircle vs. plasmid DNA vectors in a mouse model of acute lung injury.

Stem Cell Res Ther · 2021 · PMC7962085 · PMID 33726829

Europe PMC DOI

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a strong trendp = 0.07so close (0.05 < p ≤ 0.1)

Lung airspace inflammation, evaluated by the number of neutrophils in bronchoalveolar lavage (BAL), was significantly reduced in all MSC-treated mice (MSCs transfected with empty plasmid or MC, pANGPT1, or MC-ANGPT1 compared to LPS/PBS group), while mice receiving MC-ANGPT1-transfected MSCs showed a strong trend towards reduced lung inflammation compared to pANGPT1-transfected MSCs ( p = 0.07) (Fig. 2 b).

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